Department of Cell Biology
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Welcome to the Kaltschmidt Lab!

Since several decades, our research focuses on the biology and signaling of the transcription factor NF-kB, a key player in neuroprotection, (neuro)inflammation, (stem) cell proliferation and cancer formation. We are particularly interested in understanding NF-kB-signalling in the context of  the nervous system and its disorders. Here, we apply knockout mouse lines to investigate the role of NF-kB in neuroprotection, memory formation, neuronal circuit development and neurogenesis in the adult aging hippocampus.

Our research also aims to understand the role of NF-kB in proliferation and differentiation of stem cells in the context of clinical applications. We are currently investigating this research topic using adult human neural crest-derived stem cells, human induced pluripotent stem cells and mouse embryonic stem cells but are also searching for novel human stem cells sources. On technological level, we apply CRIPR/CAS for guided deletions of NF-kB-subunits as well as single cells analysis to understand lineage choices of stem cells in the context of differentiation.

We are always looking for a highly motivated Bachelor- or Masterstudents, please feel free to contact us in case you are interested in our research topics.

 

Research

  • NF-kB in the Nervous System
  • NF-kB in Stem Cells
  • Neural Crest-derived Stem Cells
  • Subunit-specific role of NF-kB in cancer
  • Single cell analysis
  • Biomechanical Properties of Cells
  • Super-Resolution Microscopy
  • Bioinformatics of the NF-kB-System

 

News

April 2018

Recently, we successfully published the review article “Subunit-Specific Role of NF-kB in Cancer” (B. Kaltschmidt et al., 2018 ). Extending the commonly accepted role of NF-kB in cancer formation and progression, we discuss the activity and importance of different NF-kB subunits in distinct types of cancer. In particular, non-canonical NF-kB RELB signaling is described to be mostly present in hematological cancers, while solid cancers reveal constitutive canonical NF-kB RELA or c-REL activity (see below). We likewise emphasize the linkage between NF-kB signaling and cancer therapy by discussing current strategies and ongoing clinical trials with particular regards to the recently described pivotal role of NF-kB c-REL in cancer-targeting immune responses (see below). For further information, see our research topic “Subunit-Specific Role of NF-kB in Cancer”.

 

 

Congratulations to Anna Höving who was awarded by the Friedrich-Wilhelm-Helweg Foundation for the best Master degree in Molecular Cell Biology!

Anna performed her Master Thesis "Single Cell Analysis of Adult Human Neural Crest-derived Stem Cells" in our lab where she applied SmartSeq2 on single Human Neural Crest-derived Stem Cells and Stem Cell-derived Neurons to compare the Transcription Profiles in the Context of Differentiation Processes.

Contact

Department of Cell Biology
Faculty of Biology
University of Bielefeld
Universitätsstraße 25
33615 Bielefeld
Germany

Prof. Dr. Christian Kaltschmidt
Room W7-134
Fon +49 521 106-5625
Fax +49 521 106-5654
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Prof. Dr. Barbara Kaltschmidt
Room W7-132
Fon +49 521 106-5624
Fax +49 521 106-5654
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Dr. Johannes Greiner
Room W7-120
Fon +49 521 106-5624
Fax +49 521 106-5654
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